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Foram encontradas 6.472 questões

Ano: 2025 Banca: Aeronáutica Órgão: ITA Prova: Aeronáutica - 2025 - ITA - Vestibular - 1ª Fase |
Q3754104 Inglês

Leia o texto a seguir para responder à questão.




        The voluminous literature dealing with the idea of human progress is decidedly a mixed bag. While some of these writings are impressive and even inspiring, many of them are superficial, perhaps even ridiculous, in their reiteration (especially during the nineteenth century) of the comforting prospect that every day in every way we are growing better and better.



        This kind of foolishness is manifested especially in discussions of such matters as economic, political, and moral progress, and of progress in art. [...]



        From time to time, there seems to be real and measurable improvement in these areas. At other times the opposite seems equally to be the case. Thus the fervent belief of writers like the French sociophilosopher Auguste Comte in the inevitability of progress in all fields of human endeavor must be viewed as insupportable. We cannot accept it any longer, even if we once thought it was true.



        Progress in human knowledge is another matter. Here it is possible to argue cogently that progress is in the nature of things. “Not only does each individual progress from day to day”, wrote French philosopher, mathematician, and mystic Blaise Pascal, “but mankind as a whole constantly progresses... in proportion as the universe grows older.” The essence of man as a rational being, as a later historian would put it, is that he develops his potential capacities by accumulating the experience of past generations.



        Just as in our individual lives we learn more and more from day to day and from year to year because we remember some at least of what we have learned and add our new knowledge to it, so in the history of the race the collective memory retains at least some knowledge from the past to which is added every new discovery.



        The memories of individuals fail and the persons die, but the memory of the race is eternal, or at least it can be expected to endure as long as human beings continue to write books and read them, or — which becomes more and more common — store up their knowledge in other mediums for the use of future generations.



Fonte: VAN DOREN, Charles. A History of Knowledge: Past, Present and Future. New York: The Random House Publishing Group, 1991, p. XV–XVI.

Na passagem “Here, it is possible to argue cogently that progress is in the nature of things.”, a palavra COGENTLY pode ser melhor traduzida por
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Ano: 2025 Banca: Aeronáutica Órgão: ITA Prova: Aeronáutica - 2025 - ITA - Vestibular - 1ª Fase |
Q3754103 Inglês

Leia o texto a seguir para responder à questão.




        The voluminous literature dealing with the idea of human progress is decidedly a mixed bag. While some of these writings are impressive and even inspiring, many of them are superficial, perhaps even ridiculous, in their reiteration (especially during the nineteenth century) of the comforting prospect that every day in every way we are growing better and better.



        This kind of foolishness is manifested especially in discussions of such matters as economic, political, and moral progress, and of progress in art. [...]



        From time to time, there seems to be real and measurable improvement in these areas. At other times the opposite seems equally to be the case. Thus the fervent belief of writers like the French sociophilosopher Auguste Comte in the inevitability of progress in all fields of human endeavor must be viewed as insupportable. We cannot accept it any longer, even if we once thought it was true.



        Progress in human knowledge is another matter. Here it is possible to argue cogently that progress is in the nature of things. “Not only does each individual progress from day to day”, wrote French philosopher, mathematician, and mystic Blaise Pascal, “but mankind as a whole constantly progresses... in proportion as the universe grows older.” The essence of man as a rational being, as a later historian would put it, is that he develops his potential capacities by accumulating the experience of past generations.



        Just as in our individual lives we learn more and more from day to day and from year to year because we remember some at least of what we have learned and add our new knowledge to it, so in the history of the race the collective memory retains at least some knowledge from the past to which is added every new discovery.



        The memories of individuals fail and the persons die, but the memory of the race is eternal, or at least it can be expected to endure as long as human beings continue to write books and read them, or — which becomes more and more common — store up their knowledge in other mediums for the use of future generations.



Fonte: VAN DOREN, Charles. A History of Knowledge: Past, Present and Future. New York: The Random House Publishing Group, 1991, p. XV–XVI.

Os termos abaixo, retirados do primeiro parágrafo, exercem no texto as funções indicadas após a seta, EXCETO em
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Ano: 2025 Banca: Aeronáutica Órgão: ITA Prova: Aeronáutica - 2025 - ITA - Vestibular - 1ª Fase |
Q3754102 Inglês

Leia o texto a seguir para responder à questão.




        The voluminous literature dealing with the idea of human progress is decidedly a mixed bag. While some of these writings are impressive and even inspiring, many of them are superficial, perhaps even ridiculous, in their reiteration (especially during the nineteenth century) of the comforting prospect that every day in every way we are growing better and better.



        This kind of foolishness is manifested especially in discussions of such matters as economic, political, and moral progress, and of progress in art. [...]



        From time to time, there seems to be real and measurable improvement in these areas. At other times the opposite seems equally to be the case. Thus the fervent belief of writers like the French sociophilosopher Auguste Comte in the inevitability of progress in all fields of human endeavor must be viewed as insupportable. We cannot accept it any longer, even if we once thought it was true.



        Progress in human knowledge is another matter. Here it is possible to argue cogently that progress is in the nature of things. “Not only does each individual progress from day to day”, wrote French philosopher, mathematician, and mystic Blaise Pascal, “but mankind as a whole constantly progresses... in proportion as the universe grows older.” The essence of man as a rational being, as a later historian would put it, is that he develops his potential capacities by accumulating the experience of past generations.



        Just as in our individual lives we learn more and more from day to day and from year to year because we remember some at least of what we have learned and add our new knowledge to it, so in the history of the race the collective memory retains at least some knowledge from the past to which is added every new discovery.



        The memories of individuals fail and the persons die, but the memory of the race is eternal, or at least it can be expected to endure as long as human beings continue to write books and read them, or — which becomes more and more common — store up their knowledge in other mediums for the use of future generations.



Fonte: VAN DOREN, Charles. A History of Knowledge: Past, Present and Future. New York: The Random House Publishing Group, 1991, p. XV–XVI.

The sentence which describes an idea which is NOT in the text is


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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747868 Inglês
Mental health project launched for diverse groups

    A new initiative ________ improving access to mental health services for people from diverse backgrounds has been unveiled. The Community Connectors Project held a launch event at Northampton's Grosvenor Centre on Friday to help individuals connect with mental health support.
Disponível em: https://www.bbc.com/news/articles/c4g05plj055o. Acesso em: 31 mar. 2025. Adaptado.

Choose the correct alternative to complete the gap in the passage. 
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747867 Inglês
How companies are embracing generative AI for employees…or not

    New York CNN - Companies are struggling to deal with the rapid rise of generative AI, with some rushing to embrace the technology as workflow tools for employees while others shun it - at least for now.
    As generative artificial intelligence - the technology that underpins ChatGPT and similar tools - seeps into seemingly every corner of the internet, large corporations are grappling with whether the increased efficiency it offers outweighs possible copyright and security risks. Some companies are enacting internal bans on generative AI tools as they work to better understand the technology, and others have already begun to introduce the trendy tech to employees in their own ways.
Disponível em: https://edition.cnn.com/2023/09/22/tech/generative-ai-corporate-policy/index.html. Acesso em: 30 mar. 2025. Adaptado.

In the text, the term enacting is equivalent to which word?  
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747866 Inglês
Bacteria use antimicrobial agent to kill competition

    Hospitalized patients are often given antibiotics, which reduces the diversity of bacteria in their microbiomes. It also allows drug-resistant strains to gain a foothold and take over. Enterococcus faecium is a gut bacterium that can cause lethal infections if it gets into the bloodstream. Vancomycin-resistant E. faecium (VREfm), which is resistant to vancomycin and multiple other antibiotics, is a growing problem in healthcare settings. Populations of VREfm within healthcare systems are known to change over time. But the factors driving these changes aren’t well understood.
    NIH-supported researchers at the University of Pittsburgh Medical Center have been collecting and sequencing bacterial DNA from hospitalized patients through the Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT). This helps clinicians to recognize and stop potential outbreaks. As part of this effort, researchers collected more than 700 VREfm samples between 2017 and 2022. A team at the university, led by Dr. Daria Van Tyne, used data from these samples to track VREfm evolution. Their findings appeared in Nature Microbiology on March 21, 2025.
    Genome sequencing of the samples identified 42 different genetic lineages, or strains, of VREfm. Almost half of the samples were closely related to at least one other sample. This suggests a high level of transmission within the hospital. Before 2020, about a third of the samples belonged to the strain ST17. From 2020 onward, two new strains, ST80 and ST117, began to take over. By the end of 2022, these two strains made up more than 80% of all samples, while ST17 was not detected.
    The researchers found that ST80 and ST117 could kill ST17, but not vice versa. Further examination revealed that ST80 and ST117, but not ST17, produce an antimicrobial peptide (a short chain of amino acids) called bacteriocin T8. Both in laboratory cultures and the guts of mice, strains that made bacteriocin T8 outcompeted strains that didn’t.
    Next, the team analyzed more than 15,000 publicly available VREfm genomes collected worldwide between 2002 and 2022. They saw the same trend, with ST17 replaced by ST80 and ST117. This suggests that the changes observed in a single hospital reflected global trends.
Disponível em: https://www.nih.gov/news-events/nih-research-matters/bacteria-use-antimicrobialagent-kill-competition. Acesso em: 3 abr. 2025.

According to the text, how do strains ST80 and ST117 outcompete ST17?  
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747865 Inglês
WHO's health emergency appeals
    WHO’s health emergency appeals consolidate WHO’s response priorities and funding requirements for the protection of vulnerable populations affected by acute and protracted health emergencies around the world.
Disponível em: https://www.who.int/emergencies/funding/health-emergency-appeals. Acesso em: 2 abr. 2025. Adaptado.

What alternative correctly conveys the meaning of acute and protracted health emergencies in Portuguese? 
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747864 Inglês
Turn Employee Feedback into
    Action Enhancing how a company supports and engages its employees can attract talent, improve retention, spur innovation, and increase customer satisfaction. But managing the employee experience for maximum benefit requires leaders to know what employees are seeing, feeling, and wanting — and then respond judiciously. Driven by a tight labor market, corporate leaders have recently invested enormous amounts of energy and resources in collecting employee feedback through pulse surveys, town halls, listening tours, focus groups, data scraping from message boards, and other methods. The problem for many leaders is that when they ask what employees think, they don’t know what to do with what they hear — they often struggle to translate all this input into meaningful insights and concrete actions. A gap between accumulating the information and taking coherent action to respond can diminish the value of employee feedback over time — and if it persists, employees may stop responding.
Disponível em: https://hbr.org/2024/11/turn-employee-feedback-into-action. Acesso em: 31 mar. 2025. Adaptado.

According to the text, what is the main challenge leaders face when collecting employee feedback?  
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747863 Inglês
NCDs at a Glance 2025. NCDs surveillance and monitoring: Noncommunicable disease mortality and risk factor prevalence in the Americas
    Effective surveillance and monitoring of noncommunicable diseases (NCDs) and their risk factors are essential for informing evidence-based public health policies, addressing health inequities, and ensuring progress toward global and regional targets. By tracking trends in NCDs, their modifiable risk factors such as tobacco use, unhealthy diets, physical inactivity, harmful use of alcohol, and air pollution, along with biological risk factors such as overweight and obesity, high blood pressure (hypertension), and elevated blood glucose (diabetes), policymakers can identify emerging threats, target vulnerable populations, allocating resources efficiently. Reliable data also enable countries to evaluate interventions, adjust policies, and strengthen health systems to reduce the burden of NCDs. This brochure presents data on NCD and suicide mortality, along with trends by sex, in the Region of the Americas and 35 Member States of the Pan American Health Organization (PAHO) from 2000 to 2021. It also highlights progress toward the 2025 global NCD targets. While the number of NCD-related deaths in the region increased to six million in 2021, the age-standardized NCD mortality rate declined by 16.2%, reflecting the impact of population growth and aging. However, premature NCD mortality — the key indicator for the Global Action Plan for NCD Prevention and Control — declined by only 0.71% annually between 2010 and 2021, falling short of the 1.92% annual reduction required to meet the 2025 target. Among modifiable risk factors, tobacco use showed the most significant decline from 2000 to 2021, while insufficient physical activity has been on the rise. Metabolic risks, including high fasting blood glucose, overweight, and obesity, exhibited concerning upward trends during this period. Hypertension control remains suboptimal, with only 36.4% of individuals achieving adequate blood pressure levels (≤140/90 mmHg). While ambient air pollution slightly decreased between 2000 and 2019, current levels remain above WHO guideline thresholds. To achieve global and regional NCD targets and improve population health in the Americas, countries must prioritize cost-effective interventions to reduce NCD mortality and address these persistent challenges.
Disponível em: https://iris.paho.org/handle/10665.2/65818. Acesso em: 2 abr. 2025.

What is the main purpose of surveillance and monitoring in the context of noncommunicable diseases (NCDs) as described in the text?  
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747862 Inglês
Utah becomes the first state to ban fluoride in public drinking water

    Utah has become the first state to ban fluoride in public drinking water, over opposition from dentists and national health organizations who warn the move will lead to medical problems and disproportionately affect low-income communities.
    Republican Gov. Spencer Cox signed legislation late Thursday that bars cities and communities from deciding whether to add the mineral to their water systems.
    Fluoride strengthens teeth and reduces cavities by replacing minerals lost during normal wear and tear, according to the U.S. Centers for Disease Control and Prevention.
Disponível em: https://edition.cnn.com/2025/03/28/health/utah-fluoride-drinking-water/index.html. Acesso em: 29 mar. 2025. Adaptado.

What does ban fluoride mean in the text? 
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Ano: 2025 Banca: FUNDEPES Órgão: Qualin Prova: FUNDEPES - 2025 - Qualin - Vestibular - Medicina - Segundo Semestre - 1º Dia |
Q3747861 Inglês

Imagem associada para resolução da questão

Disponível em: https://andertoons.com/sonogram/cartoon/9093/baby-ultrasound-with-phone. Acesso em: 29 mar. 2025.



Based on the cartoon, the doctor feels 

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Q3747663 Inglês
INSTRUCTION: Read the following text to answer the question.

How can neuroscience lead to treatments for nicotine addiction?
Around a billion people still smoke, so we clearly have more to learn about effective treatments for nicotine addiction. Medications that can help include bupropion, a classical antidepressant, which mostly helps people who are depressed to stop smoking; and varenicline, which imitates nicotine in some ways but prevents nicotinic receptors from being fully activated.
Some nicotine cessation products, such as gums and patches and inhalers, use nicotine itself in the hope that it can be delivered in small enough quantities and over a long enough period of time that nicotine receptors will only be partially chaperoned, helping to reduce upregulation while the individual works on quitting smoking.
We still need more and better science to figure out the pharmacokinetics of nicotine: How fast does it enter the body? How long does it stay in the body? To that end, along with a team of collaborators — including Caltech professors Wei Gao (professor of medical engineering), Dennis Dougherty (George Grant Hoag Professor of Chemistry), and Stephen Mayo (Bren Professor of Biology and Chemistry), and Professor Neal Benowitz of UC San Francisco — we have been working to develop a wearable device that resembles the continuous glucose monitor used by Type 1 diabetes patients.
We will use this monitor to measure nicotine while a person smokes or vapes or uses a nicotine pouch so that we can fully understand how an individual metabolizes nicotine and relate this knowledge to a century’s worth of work on nicotinic receptors and nicotine addiction.
Available at: https://scienceexchange.caltech.edu/topics/neuroscience/neuroscience-experts/nicotine-addictionneuroscience-henry-lester#what-happens-in-the-brainwhen-people-smoke. Accessed on: Aug 1st, 2025
What is the primary purpose of the new wearable gadget being developed by the author and his tea 
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Q3747662 Inglês
INSTRUCTION: Read the following text to answer the question.

How can neuroscience lead to treatments for nicotine addiction?
Around a billion people still smoke, so we clearly have more to learn about effective treatments for nicotine addiction. Medications that can help include bupropion, a classical antidepressant, which mostly helps people who are depressed to stop smoking; and varenicline, which imitates nicotine in some ways but prevents nicotinic receptors from being fully activated.
Some nicotine cessation products, such as gums and patches and inhalers, use nicotine itself in the hope that it can be delivered in small enough quantities and over a long enough period of time that nicotine receptors will only be partially chaperoned, helping to reduce upregulation while the individual works on quitting smoking.
We still need more and better science to figure out the pharmacokinetics of nicotine: How fast does it enter the body? How long does it stay in the body? To that end, along with a team of collaborators — including Caltech professors Wei Gao (professor of medical engineering), Dennis Dougherty (George Grant Hoag Professor of Chemistry), and Stephen Mayo (Bren Professor of Biology and Chemistry), and Professor Neal Benowitz of UC San Francisco — we have been working to develop a wearable device that resembles the continuous glucose monitor used by Type 1 diabetes patients.
We will use this monitor to measure nicotine while a person smokes or vapes or uses a nicotine pouch so that we can fully understand how an individual metabolizes nicotine and relate this knowledge to a century’s worth of work on nicotinic receptors and nicotine addiction.
Available at: https://scienceexchange.caltech.edu/topics/neuroscience/neuroscience-experts/nicotine-addictionneuroscience-henry-lester#what-happens-in-the-brainwhen-people-smoke. Accessed on: Aug 1st, 2025
The text suggests that products designed to help people quit nicotine, such as gums and patches, are effective by 
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Ano: 2025 Banca: FUNDEP (Gestão de Concursos) Órgão: EMESCAM Prova: FUNDEP (Gestão de Concursos) - 2025 - EMESCAM - Vestibular Medicina - Primeiro Semestre |
Q3747661 Inglês
INSTRUCTION: Read the following text to answer the question.

What happens in the brain when people smoke?
When nicotine enters the lungs, it’s in the brain 20 seconds later. In this journey, nicotine has traveled through the cells in the lungs to the blood — and then from the blood to the brain, passing through the blood‑brain barrier. In all, nicotine passes through six membranes when it’s smoked or vaped.
Once nicotine is in the brain, it activates the most sensitive nicotinic receptors on membranes of nerve cells, or neurons, but it also travels through the membrane to enter the neuron. Finally, it passes into the organelles of the neuron, where proteins, including the nicotinic receptor, are being made. When a person smokes, nicotine actually helps the cell to assemble more nicotinic receptors, which travel out of the endoplasmic reticulum (part of the cellular transportation system) and onto the surface of the cell. It’s as though nicotine is acting as a pharmacological “chaperone” to bring those receptors to the surface of the cell.
We have labeled this process “inside out” pharmacology. In trying to unravel the cell biology of nicotine addiction, my lab and others study how this so‑called chaperoning or upregulating of nicotinic receptors is necessary for the early stages of nicotine dependence, ultimately underlying the brain’s addiction to nicotine. When a person stops taking nicotine, the natural acetylcholine cannot sufficiently activate the upregulated receptors. They produce craving and other symptoms of withdrawal.
Available at: https://scienceexchange.caltech.edu/topics/ neuroscience/neuroscience-experts/nicotine-addictionneuroscience-henry-lester#what-happens-in-the-brainwhen-people-smoke. Accessed on: Aug 1st, 2025.
The word unravel in the sentence “In trying to unravel the cell biology of nicotine addiction...” is closest in meaning to 
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Q3747660 Inglês
INSTRUCTION: Read the following text to answer the question.

What happens in the brain when people smoke?
When nicotine enters the lungs, it’s in the brain 20 seconds later. In this journey, nicotine has traveled through the cells in the lungs to the blood — and then from the blood to the brain, passing through the blood‑brain barrier. In all, nicotine passes through six membranes when it’s smoked or vaped.
Once nicotine is in the brain, it activates the most sensitive nicotinic receptors on membranes of nerve cells, or neurons, but it also travels through the membrane to enter the neuron. Finally, it passes into the organelles of the neuron, where proteins, including the nicotinic receptor, are being made. When a person smokes, nicotine actually helps the cell to assemble more nicotinic receptors, which travel out of the endoplasmic reticulum (part of the cellular transportation system) and onto the surface of the cell. It’s as though nicotine is acting as a pharmacological “chaperone” to bring those receptors to the surface of the cell.
We have labeled this process “inside out” pharmacology. In trying to unravel the cell biology of nicotine addiction, my lab and others study how this so‑called chaperoning or upregulating of nicotinic receptors is necessary for the early stages of nicotine dependence, ultimately underlying the brain’s addiction to nicotine. When a person stops taking nicotine, the natural acetylcholine cannot sufficiently activate the upregulated receptors. They produce craving and other symptoms of withdrawal.
Available at: https://scienceexchange.caltech.edu/topics/ neuroscience/neuroscience-experts/nicotine-addictionneuroscience-henry-lester#what-happens-in-the-brainwhen-people-smoke. Accessed on: Aug 1st, 2025.
What is the primary function of nicotine in the process the author calls “inside out” pharmacology?
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Q3747659 Inglês
Read the following text.
Henry Lester, professor of biology at Caltech, discusses the effects of nicotine addiction on the brain.
Tobacco originated in the Americas, where humans have known some of its effects for at least 10,000 years. Beginning some 500 years ago, ocean crossings spread tobacco use to all other continents. We are essentially the only species that has learned how to use small amounts of plant toxins — which provide the selective advantage of sickening or poisoning animals who might eat them — for our own purposes. For tobacco, that toxin is nicotine. In addition to their historical medicinal and ritual uses, these substances, over time, have come to serve as guides, models, and touchstones for learning about the brain and opening many fields of neuroscience.
We have learned from tobacco and nicotine that it is possible to isolate single chemicals from plants that cause toxic effects on herbivores and valued effects on people. We’ve learned that it’s possible to define chemical processes in the human brain that are activated, inhibited, or otherwise manipulated by those substances.
Available at: https://scienceexchange.caltech.edu/topics/neuroscience/neuroscience-experts/nicotine-addictionneuroscience-henry-lester#what-happens-in-the-brain-when-people-smoke. Accessed on: Aug 1st, 2025.
According to the text, what is one of the main discoveries made from the study of tobacco and nicotine?
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Q3747588 Inglês
INSTRUCTION: Read the following text to answer the questions.

What is fatal familial insomnia?

In the mid‑1980s, a family with a mysterious problem lived in a small town in Italy. For many years, members of this family had trouble sleeping, but no one knew why. One day, a family member named Silvano decided to find out what was causing this strange problem. Silvano traveled to the city of Bologna to meet with the best sleep doctors. He told them all about his family’s mystery.
The doctors were intrigued by Silvano’s story and immediately began to study his case. After much research, the doctors discovered something never seen before: a tiny change in a special gene passed down from generation to generation in Silvano’s family, which stopped them from sleeping. They called this disease fatal familial insomnia (FFI).
Fatal familial insomnia is an extremely rare disease. Like many other rare diseases, FFI is passed on through the DNA from parents to their children. The symptoms of FFI start slowly and get worse over time. People with FFI start to have difficulty falling and / or staying asleep, and then, as it gets worse, they may suddenly fall asleep without warning. People with FFI also tend to develop other problems like a fast heartbeat; high blood pressure; hormonal, mood and behavior swings; anxiety; excessive sweating; and trouble thinking clearly and moving their bodies. The symptoms usually start between the ages of 51 and 60, although rarely they can start as early as 18 – 20 years old. FFI affects both men and women equally. To date, more than 70 families around the world have been found to have FFI.
[...]
Although there is still no cure for FFI, research is happening all over the world. Researchers are working to find new pieces to help them solve the complex puzzle of FFI and to develop treatments that can improve the lives of those affected. Ongoing research aims to understand the underlying mechanisms of FFI, especially how genetic mutations change healthy prion proteins into abnormal ones and how the buildup of abnormal prions in the brain causes FFI symptoms. This understanding is essential for developing effective therapies.
Additionally, researchers are searching for biomarkers of FFI. Biomarkers are things that can be measured through blood tests or brain scans, for example, that indicate the presence of a disease or the risk of developing it. Biomarkers could help doctors to diagnose FFI earlier and to track how it changes over time.
In terms of developing therapies for FFI, gene therapy is a promising approach that aims to fix or replace defective genes. Gene therapy could eventually improve patients’ quality of life. Researchers are also studying drugs that might stop or slow down the buildup of PrPSc in the brain. New drugs are first tested on animals to see if they work and are safe, and drugs that pass these initial tests are then tested on people. With effective new medicines, it might be possible to slow down or even stop FFI.

Available at: https://kids.frontiersin.org/articles/10.3389/frym.2025.1523273. Accessed on: Aug 4th, 2025. [Adapted]
According to the text, what is the main goal of the current research on FFI?
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Q3747587 Inglês
INSTRUCTION: Read the following text to answer the questions.

What is fatal familial insomnia?

In the mid‑1980s, a family with a mysterious problem lived in a small town in Italy. For many years, members of this family had trouble sleeping, but no one knew why. One day, a family member named Silvano decided to find out what was causing this strange problem. Silvano traveled to the city of Bologna to meet with the best sleep doctors. He told them all about his family’s mystery.
The doctors were intrigued by Silvano’s story and immediately began to study his case. After much research, the doctors discovered something never seen before: a tiny change in a special gene passed down from generation to generation in Silvano’s family, which stopped them from sleeping. They called this disease fatal familial insomnia (FFI).
Fatal familial insomnia is an extremely rare disease. Like many other rare diseases, FFI is passed on through the DNA from parents to their children. The symptoms of FFI start slowly and get worse over time. People with FFI start to have difficulty falling and / or staying asleep, and then, as it gets worse, they may suddenly fall asleep without warning. People with FFI also tend to develop other problems like a fast heartbeat; high blood pressure; hormonal, mood and behavior swings; anxiety; excessive sweating; and trouble thinking clearly and moving their bodies. The symptoms usually start between the ages of 51 and 60, although rarely they can start as early as 18 – 20 years old. FFI affects both men and women equally. To date, more than 70 families around the world have been found to have FFI.
[...]
Although there is still no cure for FFI, research is happening all over the world. Researchers are working to find new pieces to help them solve the complex puzzle of FFI and to develop treatments that can improve the lives of those affected. Ongoing research aims to understand the underlying mechanisms of FFI, especially how genetic mutations change healthy prion proteins into abnormal ones and how the buildup of abnormal prions in the brain causes FFI symptoms. This understanding is essential for developing effective therapies.
Additionally, researchers are searching for biomarkers of FFI. Biomarkers are things that can be measured through blood tests or brain scans, for example, that indicate the presence of a disease or the risk of developing it. Biomarkers could help doctors to diagnose FFI earlier and to track how it changes over time.
In terms of developing therapies for FFI, gene therapy is a promising approach that aims to fix or replace defective genes. Gene therapy could eventually improve patients’ quality of life. Researchers are also studying drugs that might stop or slow down the buildup of PrPSc in the brain. New drugs are first tested on animals to see if they work and are safe, and drugs that pass these initial tests are then tested on people. With effective new medicines, it might be possible to slow down or even stop FFI.

Available at: https://kids.frontiersin.org/articles/10.3389/frym.2025.1523273. Accessed on: Aug 4th, 2025. [Adapted]
The word although in the sentence “Although there is still no cure for FFI, research is happening all over the world.” refers to
Alternativas
Ano: 2025 Banca: FUNDEP (Gestão de Concursos) Órgão: FAME Prova: FUNDEP (Gestão de Concursos) - 2025 - FAME - Vestibular - Primeiro Semestre - Medicina |
Q3747586 Inglês
INSTRUCTION: Read the following text to answer the questions.

What is fatal familial insomnia?

In the mid‑1980s, a family with a mysterious problem lived in a small town in Italy. For many years, members of this family had trouble sleeping, but no one knew why. One day, a family member named Silvano decided to find out what was causing this strange problem. Silvano traveled to the city of Bologna to meet with the best sleep doctors. He told them all about his family’s mystery.
The doctors were intrigued by Silvano’s story and immediately began to study his case. After much research, the doctors discovered something never seen before: a tiny change in a special gene passed down from generation to generation in Silvano’s family, which stopped them from sleeping. They called this disease fatal familial insomnia (FFI).
Fatal familial insomnia is an extremely rare disease. Like many other rare diseases, FFI is passed on through the DNA from parents to their children. The symptoms of FFI start slowly and get worse over time. People with FFI start to have difficulty falling and / or staying asleep, and then, as it gets worse, they may suddenly fall asleep without warning. People with FFI also tend to develop other problems like a fast heartbeat; high blood pressure; hormonal, mood and behavior swings; anxiety; excessive sweating; and trouble thinking clearly and moving their bodies. The symptoms usually start between the ages of 51 and 60, although rarely they can start as early as 18 – 20 years old. FFI affects both men and women equally. To date, more than 70 families around the world have been found to have FFI.
[...]
Although there is still no cure for FFI, research is happening all over the world. Researchers are working to find new pieces to help them solve the complex puzzle of FFI and to develop treatments that can improve the lives of those affected. Ongoing research aims to understand the underlying mechanisms of FFI, especially how genetic mutations change healthy prion proteins into abnormal ones and how the buildup of abnormal prions in the brain causes FFI symptoms. This understanding is essential for developing effective therapies.
Additionally, researchers are searching for biomarkers of FFI. Biomarkers are things that can be measured through blood tests or brain scans, for example, that indicate the presence of a disease or the risk of developing it. Biomarkers could help doctors to diagnose FFI earlier and to track how it changes over time.
In terms of developing therapies for FFI, gene therapy is a promising approach that aims to fix or replace defective genes. Gene therapy could eventually improve patients’ quality of life. Researchers are also studying drugs that might stop or slow down the buildup of PrPSc in the brain. New drugs are first tested on animals to see if they work and are safe, and drugs that pass these initial tests are then tested on people. With effective new medicines, it might be possible to slow down or even stop FFI.

Available at: https://kids.frontiersin.org/articles/10.3389/frym.2025.1523273. Accessed on: Aug 4th, 2025. [Adapted]
Referring to the text, what is the primary cause of fatal familial insomnia (FFI)?
Alternativas
Ano: 2025 Banca: FUNDEP (Gestão de Concursos) Órgão: FAME Prova: FUNDEP (Gestão de Concursos) - 2025 - FAME - Vestibular - Primeiro Semestre - Medicina |
Q3747585 Inglês

INSTRUCTION: Read the following text to answer the question.


Abstract


Rare diseases are diseases that affect fewer than 1 in 2,000 people. Due to their rarity, it can be extremely challenging for doctors to diagnose these diseases in their patients — it often takes 6 – 8 years for some patients to get a diagnosis. Even though they are uncommon, rare diseases still have a significant impact on families and communities and need greater attention. Fatal familial insomnia (FFI) is a rare disease that affects the brain and gradually reduces a person’s ability to sleep. FFI gets worse over time and causes severe complications. There is currently no cure for FFI, so more research is crucial — not only for understanding FFI but also for unlocking potential treatments for other rare diseases. Rare disease research brings hope for a better future to those living with FFI and other rare conditions.


Available at: https://kids.frontiersin.org/articles/10.3389/frym.2025.1523273. Accessed on: Aug 2nd, 2025.

As used in the abstract, what is the best definition for the word diagnose?
Alternativas
Respostas
141: C
142: C
143: D
144: D
145: A
146: D
147: C
148: E
149: C
150: C
151: B
152: B
153: C
154: B
155: D
156: B
157: C
158: C
159: B
160: C