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Q3650827 Inglês
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Big Data Begins to Crack the Case of Endometriosis

Records from millions of patients at University of California health centers found correlations between endometriosis, one of the most common diseases in women, and a bounty of other diseases.

By Levi Gadye

Scientists at UC San Francisco have found that endometriosis — a painful chronic disease that often goes undiagnosed yet is estimated to affect as many as 200 million women worldwide — frequently occurs alongside conditions like cancer, Crohn's disease, and migraine.

The research could improve diagnosis and, ultimately, treatments for endometriosis, preventing women from having to go on long diagnostic journeys in which they are told that nothing is wrong with them.

The study, which appeared in Cell Reports Medicine on July 31, used computational methods developed at UCSF to analyze anonymized patient records collected at the University of California's six health centers.

"We now have both the tools and the data to make a difference for the huge population that suffers from endometriosis," said Marina Sirota, PhD, the interim director of the UCSF Bakar Computational Health Sciences Institute (BCHSI), professor of pediatrics, and senior author of the paper. "We hope this can spur a sea change in how we approach this disorder."

"The impact on patients' lives is huge"

Endometriosis, often called 'endo,' occurs when the endometrium, the blood-rich tissue that grows in the uterus before being expelled each month during menstruation, spreads to other nearby organs. It causes chronic pain and infertility. It is estimated that nearly 10% of women worldwide suffer from it.

"Endo is extremely debilitating," said Linda Giudice, MD, PhD, MSc, a physician-scientist in the Department of Obstetrics, Gynecology and Reproductive Sciences at UCSF and co-author of the paper. "The impact on patients' lives is huge, from their interpersonal relationships to being able to hold a job, have a family, and maintain psychological wellbeing."

The gold standard to diagnose endometriosis is surgery to find endometrial tissue outside of the uterus, and it is mainly treated with hormones to suppress the menstrual cycle, or surgery to remove the excess tissue.

But not everyone responds to hormonal therapy, which can have debilitating side effects. Even after surgery, the condition can flare up. Removal of the uterus is a last-ditch measure that is usually reserved for older women; but some women continue to experience pain even after a hysterectomy.

Giudice partnered with Sirota to leverage the UC health system's anonymized patient data against endo, which can vary dramatically across patients. Both Giudice and Sirota are principal investigators at the UCSF-Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT).

"This data is messy; it was not collected for research purposes but for the real, human purpose of helping women who need care," Sirota said. "We had the rare chance to rigorously assess how endometriosis presents across UCSF's patient population and then ask whether these observations held true with patients seen at the other UC health centers."

Data connects the dots for understanding endometriosis

Using algorithms developed for the task, Umair Khan, a bioinformatics graduate student in Sirota's lab and first author of the paper, hunted for connections linking endometriosis with the rest of each patient's health history.

He compared endo patients with patients who did not have it, and categorized the patients with endo into groups based on shared health histories. He mapped his findings from the UCSF data against the rest of the UC's health data to see if they held up across California.

"We found over 600 correlations between endometriosis and other conditions," Khan said. "These ranged from what we already knew or suspected, like infertility, autoimmune disease, and acid-reflux, to the unexpected, like certain cancers, asthma, and eye-related diseases."

Some patients had migraines, bolstering previous studies suggesting that migraine drugs might help treat endometriosis.

"In the past, studies like this would have been nearly impossible," said Tomiko Oskotsky, MD, an investigator at ENACT, associate professor in UCSF BCHSI, and co-author of the paper. "It was only 12 years ago that de-identified electronic health records became available at this scale."

The study supports the growing understanding of endometriosis as a "multi-system" disorder — a disease arising from dysfunction throughout the body.

"This is the kind of data we need to move the needle, which hasn't moved in decades," Giudice said. "We're finally getting closer to faster diagnosis and, eventually, we hope, tailored treatment for the millions of women who suffer from endometriosis."


https://www.ucsf.edu/news/2025/07/430471/big-data-begins-crack-case -endometriosis
From the statement "Endo is extremely debilitating," said Linda Giudice, what can be inferred about the author's perspective in including this quotation?
Alternativas
Q3650826 Inglês
O texto seguinte servirá de base para responder à questão.

Big Data Begins to Crack the Case of Endometriosis

Records from millions of patients at University of California health centers found correlations between endometriosis, one of the most common diseases in women, and a bounty of other diseases.

By Levi Gadye

Scientists at UC San Francisco have found that endometriosis — a painful chronic disease that often goes undiagnosed yet is estimated to affect as many as 200 million women worldwide — frequently occurs alongside conditions like cancer, Crohn's disease, and migraine.

The research could improve diagnosis and, ultimately, treatments for endometriosis, preventing women from having to go on long diagnostic journeys in which they are told that nothing is wrong with them.

The study, which appeared in Cell Reports Medicine on July 31, used computational methods developed at UCSF to analyze anonymized patient records collected at the University of California's six health centers.

"We now have both the tools and the data to make a difference for the huge population that suffers from endometriosis," said Marina Sirota, PhD, the interim director of the UCSF Bakar Computational Health Sciences Institute (BCHSI), professor of pediatrics, and senior author of the paper. "We hope this can spur a sea change in how we approach this disorder."

"The impact on patients' lives is huge"

Endometriosis, often called 'endo,' occurs when the endometrium, the blood-rich tissue that grows in the uterus before being expelled each month during menstruation, spreads to other nearby organs. It causes chronic pain and infertility. It is estimated that nearly 10% of women worldwide suffer from it.

"Endo is extremely debilitating," said Linda Giudice, MD, PhD, MSc, a physician-scientist in the Department of Obstetrics, Gynecology and Reproductive Sciences at UCSF and co-author of the paper. "The impact on patients' lives is huge, from their interpersonal relationships to being able to hold a job, have a family, and maintain psychological wellbeing."

The gold standard to diagnose endometriosis is surgery to find endometrial tissue outside of the uterus, and it is mainly treated with hormones to suppress the menstrual cycle, or surgery to remove the excess tissue.

But not everyone responds to hormonal therapy, which can have debilitating side effects. Even after surgery, the condition can flare up. Removal of the uterus is a last-ditch measure that is usually reserved for older women; but some women continue to experience pain even after a hysterectomy.

Giudice partnered with Sirota to leverage the UC health system's anonymized patient data against endo, which can vary dramatically across patients. Both Giudice and Sirota are principal investigators at the UCSF-Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT).

"This data is messy; it was not collected for research purposes but for the real, human purpose of helping women who need care," Sirota said. "We had the rare chance to rigorously assess how endometriosis presents across UCSF's patient population and then ask whether these observations held true with patients seen at the other UC health centers."

Data connects the dots for understanding endometriosis

Using algorithms developed for the task, Umair Khan, a bioinformatics graduate student in Sirota's lab and first author of the paper, hunted for connections linking endometriosis with the rest of each patient's health history.

He compared endo patients with patients who did not have it, and categorized the patients with endo into groups based on shared health histories. He mapped his findings from the UCSF data against the rest of the UC's health data to see if they held up across California.

"We found over 600 correlations between endometriosis and other conditions," Khan said. "These ranged from what we already knew or suspected, like infertility, autoimmune disease, and acid-reflux, to the unexpected, like certain cancers, asthma, and eye-related diseases."

Some patients had migraines, bolstering previous studies suggesting that migraine drugs might help treat endometriosis.

"In the past, studies like this would have been nearly impossible," said Tomiko Oskotsky, MD, an investigator at ENACT, associate professor in UCSF BCHSI, and co-author of the paper. "It was only 12 years ago that de-identified electronic health records became available at this scale."

The study supports the growing understanding of endometriosis as a "multi-system" disorder — a disease arising from dysfunction throughout the body.

"This is the kind of data we need to move the needle, which hasn't moved in decades," Giudice said. "We're finally getting closer to faster diagnosis and, eventually, we hope, tailored treatment for the millions of women who suffer from endometriosis."


https://www.ucsf.edu/news/2025/07/430471/big-data-begins-crack-case -endometriosis
In the excerpt "The gold standard to diagnose endometriosis is surgery to find endometrial tissue outside of the uterus", which voice is the verb "is" in?
Alternativas
Q3650825 Inglês
O texto seguinte servirá de base para responder à questão.

Big Data Begins to Crack the Case of Endometriosis

Records from millions of patients at University of California health centers found correlations between endometriosis, one of the most common diseases in women, and a bounty of other diseases.

By Levi Gadye

Scientists at UC San Francisco have found that endometriosis — a painful chronic disease that often goes undiagnosed yet is estimated to affect as many as 200 million women worldwide — frequently occurs alongside conditions like cancer, Crohn's disease, and migraine.

The research could improve diagnosis and, ultimately, treatments for endometriosis, preventing women from having to go on long diagnostic journeys in which they are told that nothing is wrong with them.

The study, which appeared in Cell Reports Medicine on July 31, used computational methods developed at UCSF to analyze anonymized patient records collected at the University of California's six health centers.

"We now have both the tools and the data to make a difference for the huge population that suffers from endometriosis," said Marina Sirota, PhD, the interim director of the UCSF Bakar Computational Health Sciences Institute (BCHSI), professor of pediatrics, and senior author of the paper. "We hope this can spur a sea change in how we approach this disorder."

"The impact on patients' lives is huge"

Endometriosis, often called 'endo,' occurs when the endometrium, the blood-rich tissue that grows in the uterus before being expelled each month during menstruation, spreads to other nearby organs. It causes chronic pain and infertility. It is estimated that nearly 10% of women worldwide suffer from it.

"Endo is extremely debilitating," said Linda Giudice, MD, PhD, MSc, a physician-scientist in the Department of Obstetrics, Gynecology and Reproductive Sciences at UCSF and co-author of the paper. "The impact on patients' lives is huge, from their interpersonal relationships to being able to hold a job, have a family, and maintain psychological wellbeing."

The gold standard to diagnose endometriosis is surgery to find endometrial tissue outside of the uterus, and it is mainly treated with hormones to suppress the menstrual cycle, or surgery to remove the excess tissue.

But not everyone responds to hormonal therapy, which can have debilitating side effects. Even after surgery, the condition can flare up. Removal of the uterus is a last-ditch measure that is usually reserved for older women; but some women continue to experience pain even after a hysterectomy.

Giudice partnered with Sirota to leverage the UC health system's anonymized patient data against endo, which can vary dramatically across patients. Both Giudice and Sirota are principal investigators at the UCSF-Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (ENACT).

"This data is messy; it was not collected for research purposes but for the real, human purpose of helping women who need care," Sirota said. "We had the rare chance to rigorously assess how endometriosis presents across UCSF's patient population and then ask whether these observations held true with patients seen at the other UC health centers."

Data connects the dots for understanding endometriosis

Using algorithms developed for the task, Umair Khan, a bioinformatics graduate student in Sirota's lab and first author of the paper, hunted for connections linking endometriosis with the rest of each patient's health history.

He compared endo patients with patients who did not have it, and categorized the patients with endo into groups based on shared health histories. He mapped his findings from the UCSF data against the rest of the UC's health data to see if they held up across California.

"We found over 600 correlations between endometriosis and other conditions," Khan said. "These ranged from what we already knew or suspected, like infertility, autoimmune disease, and acid-reflux, to the unexpected, like certain cancers, asthma, and eye-related diseases."

Some patients had migraines, bolstering previous studies suggesting that migraine drugs might help treat endometriosis.

"In the past, studies like this would have been nearly impossible," said Tomiko Oskotsky, MD, an investigator at ENACT, associate professor in UCSF BCHSI, and co-author of the paper. "It was only 12 years ago that de-identified electronic health records became available at this scale."

The study supports the growing understanding of endometriosis as a "multi-system" disorder — a disease arising from dysfunction throughout the body.

"This is the kind of data we need to move the needle, which hasn't moved in decades," Giudice said. "We're finally getting closer to faster diagnosis and, eventually, we hope, tailored treatment for the millions of women who suffer from endometriosis."


https://www.ucsf.edu/news/2025/07/430471/big-data-begins-crack-case -endometriosis
In the excerpt "This data is messy; it was not collected for research purposes but for the real, human purpose of helping women who need care", what does the pronoun "it" refer to?
Alternativas
Q3643970 Inglês
Examine this morphological breakdown:

"The unhappiness of the restructured employees was predictable."

How many bound morphemes are present in this sentence? 
Alternativas
Q3643969 Inglês
Identify the syntactic structure of this sentence:

"Although the research team had anticipated positive results, the data revealed significant anomalies that challenged their initial hypothesis."

This sentence exemplifies:
Alternativas
Q3643968 Inglês
Literary and non-literary texts serve different purposes. A short story is typically fictional and may rely on literary devices such as symbolism and metaphor to convey meaning. On the other hand, a newspaper article aims to provide factual information, prioritizing accuracy and objectivity. Which option below correctly represents this distinction?
Alternativas
Q3643967 Inglês
When dealing with online texts, readers often face challenges such as misinformation, biased arguments, and lack of credible sources. Critical reading strategies are essential for identifying the reliability of a text and distinguishing between fact and opinion. In this context, which element is explicitly required for a critical reader when approaching online materials? 
Alternativas
Q3643966 Inglês
A student needs to write a formal complaint letter to a company regarding a defective product. Which elements are ESSENTIAL for this specific genre?

I.Formal salutation and closing.
II.Clear statement of the problem with specific details.
III.Creative narrative techniques to engage the reader.
IV.Professional tone throughout the document.
V.Specific request for resolution or action.

The appropriate combination is: 
Alternativas
Q3643965 Inglês
Cohesion in texts is achieved through linguistic elements that connect sentences and ideas, such as conjunctions and adverbial connectors. Consider the following example:

"The company promised to reduce its carbon footprint. However, recent reports show an increase in emissions."

In this case, what is the function of the connector "however"?
Alternativas
Q3643964 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
 In the passage, the word "dexterity" in the phrase "manual dexterity and brain evolution" means:
Alternativas
Q3643963 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
Consider the sentence from the article:

"As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills."

Which option correctly describes its syntactic structure?
Alternativas
Q3643962 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/

Which sentence is appropriate as the opening line of a concise academic summary of the article, preserving objectivity and scope?

Alternativas
Q3643961 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
The researchers excluded human data to test whether the correlation persisted. What does this methodological choice suggest?
Alternativas
Q3643960 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
The line "Longer thumbs mean bigger brains" encodes a correlation via comparatives. Which option correctly recasts this relation using the correlative comparative pattern in standard English? 
Alternativas
Q3643959 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
Which statement is explicitly stated in the article?
Alternativas
Q3643958 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
Consider: "They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination."

Choose the option that correctly identifies the antecedents of the bolded pronouns.
Alternativas
Q3643957 Inglês
O texto seguinte servirá de base para responder à questão.


Primate thumbs and brains evolved hand-in-hand

By University of Reading Tue, Aug 26, 2025


University of Reading - Longer thumbs mean bigger brains, scientists have found − revealing how human hands and minds evolved together. Researchers studied 94 different primate species, including fossils and living animals, to understand how our ancestors developed their abilities. They found that species with relatively longer thumbs, which help with gripping small objects precisely, consistently had larger brains. The research, published today (Tuesday, 26 August) in Communications Biology, provides the first direct evidence that manual dexterity and brain evolution are connected across the entire primate lineage, from lemurs to humans. Humans and our extinct relatives boast both extraordinarily long thumbs and exceptionally large brains. However, the link remains strong across all primates: when scientists removed human data from their analysis, the connection between thumb length and brain size remained. 


Dr Joanna Baker, lead author from the University of Reading, said: "We've always known that our big brains and nimble fingers set us apart, but now we can see they didn't evolve separately. As our ancestors got better at picking up and manipulating objects, their brains had to grow to handle these new skills. These abilities have been fine-tuned through millions of years of brain evolution." 


Thumbs linked to thinking, not movement


The scientists made a surprising discovery about which part of the brain grows alongside longer thumbs. They expected longer thumbs to be linked to the cerebellum because it is the region of the brain that controls movement and coordination. Instead, longer thumbs were connected to the neocortex (a complex layered region comprising approximately half the volume of the human brain), which processes sensory information and handles cognition and consciousness. 


It was a surprise that only one of the two major brain regions they thought would be involved actually was. The findings suggest that as primates developed better manual skills for handling objects, their brains had to grow to process and use these new abilities effectively − but further work is needed to establish exactly how the neocortex supports manipulative abilities.


https://popular-archaeology.com/article/primate-thumbs-and-brains-evol ved-hand-in-hand/
The passage "Primate thumbs and brains evolved hand-in-hand" was published by the University of Reading and summarizes a scientific study. Based on its structure and purpose, the text is best classified as:
Alternativas
Q3643752 Português
Com 2.130 casos de dengue e três mortes registradas até quarta-feira, "Conchas (SP) é a cidade da região de Itapetininga com a maior incidência da doença".
Fonte: https://acesse.one/6tJbu.adaptado
Sintaticamente, é correto afirmar que, na oração destacada, o predicativo do sujeito é:
Alternativas
Q3643750 Pedagogia
A group of English learners is struggling to understand the difference between the present perfect and the simple past. The teacher organizes peer activities in which stronger students, under her guidance, help others through dialogues and role-play exercises, gradually allowing them to solve problems on their own. Which Vygotskian concept is most evident here?
Alternativas
Q3643749 Pedagogia
A Brazilian teacher introduces a lesson on food culture by asking students to compare traditional dishes from Brazil with those from the UK and the US. She encourages learners to discuss not only vocabulary but also eating habits, social contexts, and symbolic meanings. Which theoretical perspective does this practice exemplify?
Alternativas
Respostas
5481: B
5482: D
5483: B
5484: B
5485: B
5486: D
5487: A
5488: C
5489: C
5490: D
5491: A
5492: D
5493: A
5494: B
5495: A
5496: D
5497: A
5498: D
5499: B
5500: D