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Ano: 2026
Banca:
AMEOSC
Órgão:
Prefeitura de Barra Bonita - SC
Prova:
AMEOSC - 2026 - Prefeitura de Barra Bonita - SC - Professor II (Língua Estrangeira – Inglês) |
Q4392986
Inglês
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A leader in the study of longevity is returning to
UCLA Health
Renowned geroscientist and computational biologist
Steve Horvath, PhD, is returning as a professor in the
David Geffen School of Medicine at UCLA on July 1, after
4 1/2 years in the biotech industry. Previously, he was a
full-time professor of Human Genetics and Biostatistics at
UCLA for 22 years.
Geroscience is the modern term for the biology of aging.
Dr. Horvath, who was born in Germany, is internationally
known for his research into the aging process and, in
particular, epigenetics, how the environment influences
our genes, affecting a person's longevity.
His groundbreaking research, which he began at UCLA in
2011, looked at the "epigenetic age" of more than 13,000
DNA samples of people from the U.S. and Europe,
determined from the chemical modifications of their DNA
(also called DNA methylation).
People whose epigenetic age was higher than their
chronological age were shown to be at an increased risk
of death from all causes. From this, Dr. Horvath
developed the "epigenetic clock," a way of measuring
biological aging and mortality risk.
"The universal mammalian methylation clock was really a
UCLA triumph — a true team effort," said Dr. Horvath,
who received the 2026 Luminary Award at the Precision
Medicine World Conference. That project, part of the
international Mammalian Methylation Consortium that Dr.
Horvath led, drew on collaborators across UCLA,
including Jason Ernst, PhD; William Yang, MD, PhD;
Ebru Erbay, MD, PhD; Karen Sears, PhD; and Ren
Larison, PhD.
Aging is a growing field of study and the Division of
Geriatrics is a research leader.
"Aging happens at the cellular level — every tissue in the
human body shows signs of aging," explained Arun S.
Karlamangla, MD, PhD, chief of the UCLA Division of
Geriatrics. "The epigenetic profile is affected by stresses
in life. As we age, these stresses change DNA
functionality. Dr. Horvath's research showed that these
changes can be quantified and used to predict a person's
lifespan."
None of us has control over the DNA we're born with, but
we do have some control over how long we live.
"The epigenetic clock is one window into biological aging,
but it doesn't capture everything, and plenty of
well-established factors influence how long and how well
a person lives," said Dr. Horvath. "The strongest
evidence is for the basics: not smoking, maintaining a
healthy weight, a sensible diet, regular physical activity
and good sleep."
Dr. Horvath has run the test on himself and by the
epigenetic clock, he is about three years younger than
his chronological age of 58.
New medications also show promise for improving
longevity, he said. "There's active research interest in
newer GLP-1 receptor agonists — e.g., the
Ozempic/Wegovy class — which are reshaping how we
think about metabolic health," said Dr. Horvath, adding
that the same is true for anti-inflammatory and antifibrotic
drugs.
Dr. Horvath's epigenetic clocks have become standard
tools across aging research, used by teams worldwide to
test what actually changes biological aging.
They have been applied in the randomized DO-HEALTH
trial, where omega-3, vitamin D and exercise modestly
slowed epigenetic aging in adults older than 70; in the
Women's Health Initiative, where faster epigenetic aging
tracked with later cognitive impairment and dementia;
and in studies of cardiovascular disease and mortality.
This kind of population-level application aligns closely
with the Division of Geriatrics' emphasis on healthy,
independent life expectancy.
Dr. Horvath's research has also shown that the cells of
different organs age at different rates. For instance, the
liver ages faster than other organs, he said, particularly in
the case of people with obesity.
Another discovery was that the blood and brain tissues of
human males age faster than those of females, which
might be the reason women live longer on average than
men across all cultures and countries.
Leading in aging research
The study of aging at the UCLA Division of Geriatrics
focuses on understanding the epidemiology of
age-related conditions such as frailty, cognitive
impairment and dementia, and improving the delivery of
compassionate, comprehensive care to older adults.
Dr. Horvath's return to UCLA will bolster the department's
role in aging research by translating his cellular research
to clinical trials, said Dr. Karlamangla.
"We want to be pioneers in all three aspects: cellular
research, clinical and population-level research, and
health services and implementation research," Dr.
Karlamangla said. "We are one of the pioneers in clinical
innovation for the delivery of healthcare to older adults,"
he said, an approach that is called bench to bedside.
Life expectancy is important, but even more important is
good health, which is necessary for independence, Dr.
Karlamangla emphasized. This is referred to as healthy
life expectancy, or independent life expectancy.
New work at UCLA
Along with serving as a professor, Dr. Horvath will return
to UCLA Health as director of aging biology research in
the Department of Medicine, working across 11 divisions.
In this way, he will work directly with doctors to apply
aging research to their patients. The move into the
Department of Medicine is deliberate: his focus now is translating discoveries from aging biology into care for
patients.
"What I'm most looking forward to in returning to UCLA is
the people and the collaborative environment," said Dr.
Horvath. "UCLA has remarkable strength across
medicine, computational biology, stem cell biology, and
the basic science of complex diseases, and being back in
that setting with former colleagues and future students is
what excites me most.
"It feels like the right place to do the next phase of this
work: helping to translate findings from aging biology into
the clinic."
https://www.uclahealth.org/news/article/leader-study-longevity-returning
-ucla-health
A public-school English teacher uses the UCLA Health
article to design a sequence of reading tasks. In the first
stage, students identify explicit information about Dr.
Horvath's career and research. In the second, they
distinguish established evidence from tentative claims by
examining expressions such as "show promise" and
"might be the reason". In the final stage, they produce a
clear summary of the article, selecting relevant evidence
and preserving the degree of certainty expressed in the
original text.
Considering the CEFR (Common European Framework of Reference for Languages) as a framework for progression in communicative language ability, select the correct alternative.
Considering the CEFR (Common European Framework of Reference for Languages) as a framework for progression in communicative language ability, select the correct alternative.
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