Questões de Concurso
Comentadas sobre palavras conectivas | connective words em inglês
Foram encontradas 436 questões
One of my earliest memories is of my mother cleaning with
what looked to me like cooking ingredients. She would be listening
to the radio as she poured baking soda, lemon, and vinegar
combinations on the surfaces of our home. Magically these natural
cleaning products kept our home clean and smelling fresh, without
stretching an already thin household budget. Here are a few basic
household ingredients and items you can use to clean your home.
Vinegar naturally cleans like an all-purpose cleaner. Mix a
solution of 1 part water to 1 part vinegar in a new store bought
spray bottle and you have a solution that will clean most areas of
your home. Vinegar is a great natural cleaning product as well as
a disinfectant and deodorizer. Always test on an inconspicuous
area. It is safe to use on most surfaces and has the added bonus of
being incredibly cheap. Improperly diluted vinegar is acidic and
can eat away at tile grout. Never use vinegar on marble surfaces.
Don't worry about your home smelling like vinegar. The smell
disappears when it dries.
Lemon juice is another natural substance that can be used to
clean your home. Lemon juice can be used to dissolve soap scum
and hard water deposits. Lemon is a great substance to clean and
shine brass and copper. Lemon juice can be mixed with vinegar
and or baking soda to make cleaning pastes. Cut a lemon in half
and sprinkle baking soda on the cut section. Use the lemon to
scrub dishes, surfaces, and stains.
Baking soda can be used to scrub surfaces in much the same
way as commercial abrasive cleansers. Baking soda is great as a
deodorizer. Place a box in the refrigerator and freezer to absorb
odors. Put it anywhere you need deodorizing action. Try these three
kitchen ingredients as natural cleaning products in your home.
(http://housekeeping.about.com/cs/environment/a/alternateclean.30.10.2009.
Adaptado)
Oil is the largest source of liquid fuel and, in spite of attempts to develop synthetic fuels, world consumption of oil
products in increasing.
The oil industry is not much more than a hundred years old. It began when the first oil well was drilled in 1859. In the
early days, oil was used to light houses because there was no electricity and gas was very scarce. Later, people began to use oil
for heating too.
Most industries use machinery to make things. Every machine needs oil in order to run easily. Even a small clock or watch
needs a little oil from time to time.
The engines of many machines use oil fuels petrol, kerosene or diesel. Cars, buses, trucks, tractors, and small aircraft use
petroleum chemicals: synthetic rubber, plastics, synthetic fiber materials for clothes and for the home, paints, materials which
help to stop rust, photographic materials, soap and cleaning materials (detergents), drugs, fertilizers for farms and gardens, food
containers, and may others.
In 1900 the world’s oil production was less than 2 million tons a year. Today the oil industry is one of the world’s largest
and most important suppliers of raw materials.
A Laptop Designed to Take a Licking and Keep on Ticking
By JOHN BIGGS
“All terrain” is not usually a designation associated with things as delicate as hard drives and high-speed memory chips. Dell, however, is betting that its Latitude ATG D620 − the ATG stands for All-Terrain Grade − can change that. The ATG D620, which Dell says is designed to military specifications, includes a spill-resistant keyboard, heavy-duty case and 14-inch screen, which is visible in direct sunlight. It weighs about 6 pounds with the optical disk drive and battery installed, and is about 2 inches thick. The laptop comes in a metal-and-black finish with protective coverings on its serial, video out, modem, Ethernet and four U.S.B. ports. Inside the hard shell is an Intel Core 2 Duo processor, running at up to 2 gigahertz, and up to 4 gigabytes of memory. The least expensive model ($2,499) runs at 1.6 gigahertz and includes an 80-gigabyte drive and 512 megabytes of memory. Dell includes a fingerprint scanner for security, while military and other security-conscious users can enable the laptop’s built-in Smart Card reader and other data encryption technology. ...... it won’t survive a dunk in the deep, the ATG D620 can survive a splash of mud or a good, hard drop. (Adapted from The New York Times, January 25, 2007)
Majority of workers feel overwhelmed by deluge of data,
survey finds
By Eve Tahmincioglu
updated 8:18 p.m. ET March 16, 2008
Don't expect Shaun Osher, the CEO of Core Group
Marketing in New York, to answer your e-mail right away.
He has stopped responding to e-mails every minute and
only checks his e-mail account twice a day. He also started
turning off his BlackBerry during meetings.
This tactic has made him so much more productive
that earlier this year he held a meeting with his staff of 50
and "strongly suggested" that they stop relying so heavily
on e-mail and actually start calling clients on the phone.
And, he requested his employees put cell phones and
PDAs on silent mode during meetings, as well as curtail
the common practice of cc-ing everybody when sending
out an e-mail. "There was so much redundancy, so much
unnecessary work," he explains. "One person could handle
an issue that should take two minutes, but when an email
goes out and five people get cc-ed, then everybody
responds to it and there's a snowball effect."
It's not that Osher has anything against technology. In
fact, he loves it. The problem is, last year he realized he
was inundated with so many e-mails and so much
information in general that he began to experience data
overload. "In the beginning, e-mail and all this data was a
great phenomenon, revolutionizing what we do. But the
pendulum has swung way too much to the other side," he
maintains. "We're less productive."
Osher isn't the only one out there under a data
avalanche. Thanks to technological innovations, you can
be talking to a customer on your cell phone, answering a
LinkedIn invitation on your laptop, and responding to email
on your PDA all at the same time. Besides, during
tough economic times, who will want to miss any
information when your job could be on the line if you indulge
in the luxury of being offline? Turns out, seven out of 10
office workers in the United States feel overwhelmed by
information in the workplace, and more than two in five
say they are headed for a data "breaking point," according
to a recently released Workplace Productivity Survey.
Mike Walsh, CEO of LexisNexis U.S. Legal Markets,
says there are a host of reasons we're all on the information
brink: "exponential growth of the size of the information
'haystack,' the immensity and immediacy of digital
communications, and the fact that professionals are not
being provided with sufficient tools and training to help
them keep pace with the growing information burden."
Ellen Kossek, a professor from Michigan State, believes
we are less productive in this age of 24-7 technology, and
our multitasking mentality has spawned a "not-mentallypresent"
society. "We're becoming an attention-deficit
disorder society switching back and forth like crazy,"
Kossek says. "We're connected all the time. We're
working on planes, in coffee shops, working on the
weekends. Work is very seductive, but yet we're actually
less effective."
The key to getting your head above the data flood,
according to workplace experts, is managing and reducing
the information you're bombarded with.
© 2008 MSNBC Interactive - (slightly adapted)
http://www.msnbc.msn.com/id/23636252/
is having an impact on the way people think about
datacenters. Companies around the world are
announcing ways to save energy and reduce costs by
5 buying new hardware and services. Yet, there is little
guidance on how you can take action to control energy
costs. In the past, electricity has been treated as an
overhead expense, like the cost of space. But with rising
power costs and issues regarding reliability, supply, and
10 capacity, electricity requires its own specific strategy.
Projects regarding performance optimization and
cost reduction are a part of everyday best practices in
nearly every area of business. So why not treat energy
cost in the same way?
15 As Information Technologies (IT) pros, many of us
make decisions about the configuration and setup of
servers, the specifications on the equipment our
organizations purchase, and the requirements for
datacenter upgrades and construction. We even provide
20 early design input during application development. When
it comes to these projects, we obviously have a golden
opportunity to be green and influence the energy
efficiency of any datacenter.
The first part of any strategy is to know your current
25 energy usage. You need to know where your energy is
used and by what specific equipment, as well as what
usage is efficient and what is wasteful in the datacenter.
Unfortunately, it's rare to find power-consumption
metering in place that can break down usage to a level
30 where people can see the results of their actions. Most
organizations typically only see a monthly power bill
that rolls up consumption into an overall bottom line.
This offers little incentive for saving energy since
individuals never see the impact of their decisions, and
35 there is no way for them to prove that their changes
have actually saved energy.
One of the first issues people confront when
considering a green datacenter initiative is whether they
have executive support. For the purpose of the article, I
40 am going to assume the answer is "not yet." Executive
support requires a serious commitment that provides
resources and budget for your initiative. And while there
is a lot of talk about green datacenters, the reality is
that there is still often a lack of serious support at the
45 executive level. If you did already have such executive
support, you would probably be running a green
datacenter right now.
Still, even assuming you are not getting the support
you need, there is a great deal you can do to push your
50 green datacenter initiative forward. So how do you
determine effective actions to take in achieving your
goals? Fortunately, energy efficiency is not a new
concept and there is a lot that IT pros can learn from
other industries. [.]
55 Anyway, for whichever direction you choose,
planning an energy efficiency program for your datacenter
will require collaboration across groups in IT. Until
recently, the typical approach to planning IT solutions
has been to ignore power costs early on during the design
60 phase, focusing on the hardware and software being
purchased, along with the labor and hosting costs of
the solution. When power is buried in the overhead cost
of running solutions in a datacenter, energy efficiency
is a low priority. Exposing the actual power being
65 consumed by solutions is the first critical step in changing
the behavior of your organization.
By Dave Ohara
TechNet Magazine, October 2007
considere o texto abaixo.
Brian Krebs on Computer Security
Three of the most aggressive buyers of online advertising
space today agreed to ...53... fines and reform their advertising
practices as part of a landmark anti-spyware settlement.
Mobile phone giant Cingular Wireless LLC, and travel
sites Priceline.com and Travelocity.com agreed to settle their
part in an ongoing investigation by the New York State Attorney
General's office, which last year sued adware/spyware purveyor
DirectRevenue for deceptively and fraudulently installing its popup
ad serving and Web tracking software on millions of PCs
...54... approval or consent of consumers.
This is an important settlement on a number of levels.
Online help forums are awash in desperate messages from
consumers ...55... machines were besieged by pop-up ads after
visiting a Web site that used slimy drive-by tactics to install
DirectRevenue's software, which is notoriously difficult to
remove from a host machine.
Perhaps more significantly, these advertisers were just
as culpable for supporting DirectRevenue's sleazy business
practices long after anti-spyware activists like Ben Edelman,
Suzi Turner and others published evidence of the illegal
distribution methods of DirectRevenue and the Webmasters it
paid to install its software. Experts consistently documented
adware bundles like the ones distributed by DirectRevenue
being installed on computers that contract distributors had
already infected with computer viruses and worms.
Ari Schwartz, deputy director for the Center for
Democracy & Technology, a consumer policy group in
Washington, D.C., said today's settlement was important
because it recognizes the oft-overlooked role that advertisers
continue to play in supporting the adware and spyware industry.
"The dirty secret about unwanted adware is that many
legitimate companies - knowingly or not - fund its proliferation
with their advertising dollars. Until we cut off that funding, there
will always be a financial incentive for companies to bombard
users with adware that they neither want nor need," Schwartz
said in a written statement.
While the settlement is a welcome and important one, the
terms and fines could have been a bit stiffer. Under the terms of
the agreement, all three companies will have to pay between
$30,000 and $35,000 each to New York state. In addition, "prior
to contracting with a company to deliver their ads, and quarterly
thereafter, the companies must investigate how their online ads
are delivered. The companies must immediately cease using
adware programs that violate the settlement agreements or their
own adware policies."
By Brian Krebs ? January 29, 2007
(Adapted from:
http://blog.washingtonpost.com/securityfix/2007/01/web_advertisers
_settle_ny_spyw.html)
considere o texto abaixo.
Brian Krebs on Computer Security
Three of the most aggressive buyers of online advertising
space today agreed to ...Q9108... fines and reform their advertising
practices as part of a landmark anti-spyware settlement.
Mobile phone giant Cingular Wireless LLC, and travel
sites Priceline.com and Travelocity.com agreed to settle their
part in an ongoing investigation by the New York State Attorney
General's office, which last year sued adware/spyware purveyor
DirectRevenue for deceptively and fraudulently installing its popup
ad serving and Web tracking software on millions of PCs
...Q9109... approval or consent of consumers.
This is an important settlement on a number of levels.
Online help forums are awash in desperate messages from
consumers ...Q9110... machines were besieged by pop-up ads after
visiting a Web site that used slimy drive-by tactics to install
DirectRevenue's software, which is notoriously difficult to
remove from a host machine.
Perhaps more significantly, these advertisers were just
as culpable for supporting DirectRevenue's sleazy business
practices long after anti-spyware activists like Ben Edelman,
Suzi Turner and others published evidence of the illegal
distribution methods of DirectRevenue and the Webmasters it
paid to install its software. Experts consistently documented
adware bundles like the ones distributed by DirectRevenue
being installed on computers that contract distributors had
already infected with computer viruses and worms.
Ari Schwartz, deputy director for the Center for
Democracy & Technology, a consumer policy group in
Washington, D.C., said today's settlement was important
because it recognizes the oft-overlooked role that advertisers
continue to play in supporting the adware and spyware industry.
"The dirty secret about unwanted adware is that many
legitimate companies - knowingly or not - fund its proliferation
with their advertising dollars. Until we cut off that funding, there
will always be a financial incentive for companies to bombard
users with adware that they neither want nor need," Schwartz
said in a written statement.
While the settlement is a welcome and important one, the
terms and fines could have been a bit stiffer. Under the terms of
the agreement, all three companies will have to pay between
$30,000 and $35,000 each to New York state. In addition, "prior
to contracting with a company to deliver their ads, and quarterly
thereafter, the companies must investigate how their online ads
are delivered. The companies must immediately cease using
adware programs that violate the settlement agreements or their
own adware policies."
By Brian Krebs ? January 29, 2007
(Adapted from:
http://blog.washingtonpost.com/securityfix/2007/01/web_advertisers
_settle_ny_spyw.html)
By Jonathan Weisman Washington Post Staff Writer Friday, November 4, 2005; A01
The Senate approved sweeping deficit-reduction legislation last night that would save about $35 billion over the next five years by cutting federal spending on prescription drugs, agriculture supports and student loans, while clamping down on fraud in the Medicaid program. The measure would also open Alaska's Arctic National Wildlife Refuge to oil drilling, a long-sought goal of the oil industry that took a major step forward after years of political struggle. A bipartisan effort to strip the drilling provision narrowly failed. The Senate bill, which passed 52 to 47, is the first in nearly a decade to tackle the growth of entitlement spending, the part of the federal budget that rises automatically based on set formulas and population changes. It would shave payments to some farmers by 2.5 percent, while eliminating a major cotton support program and trimming agriculture conservation spending. A proposal to limit payments to rich farmers failed yesterday. The measure passed largely along party lines, with only two Democrats voting for it and five Republicans voting against it. Yesterday's action is part of an effort by congressional Republicans to demonstrate fiscal discipline after widespread complaints of profligate spending on Capitol Hill. ______ many Democrats and some moderate Republicans are concerned that the effort may go too far, prominent Republicans in the Senate and House said the cuts were necessary to slow the rate of spending and control a deficit projected to total $314 billion by the end of the fiscal year. During a speech yesterday, former House majority leader Tom Delay (R-Tex) repeatedly apologized for excessive spending by Congress, including recent highway legislation that was with lawmakers’ pet projects. After noting that House Republicans have voted to cut taxes every year since winning the majority in 1994, DeLay acknowledged, “Our record on spending has not been as consistent, .”
(Adapted from washingtonpost.com)
Na questão, a palavra que preenche corretamente a lacuna é
Avoidance and evasion compared: The United States example
The use of the terms tax avoidance and tax evasion can vary depending on the jurisdiction. In the United States, for example, the term "tax evasion" (or, more precisely, "attempted tax evasion") generally consists of criminal conduct, the purpose of which is to avoid the assessment or payment of a tax that is already legally owed at the time of the criminal conduct. (The term "assessment" is here used in the technical sense of a statutory assessment: the formal administrative act of a duly appointed employee of the Internal Revenue Service who records the tax on the books of the United States Treasury after certain administrative prerequisites have been met. In the case of Federal income tax, this act generally occurs after the close of the tax year - and usually after a tax return has been filed.)
By contrast, the term "tax avoidance" is used in the United States to describe lawful conduct, the purpose of which is to avoid the creation of a tax liability. Tax evasion involves breaking the law; tax avoidance is using legal means to avoid owing tax in the first place. An evaded tax remains a tax legally owed. An avoided tax (in the U.S. sense) is a tax liability that has never existed. A simple example of tax avoidance in this sense is the situation where a business considers selling a particular asset at a huge gain but, after consulting with a tax adviser, decides not to [VERB] the sale. ......97...... no sale occurs, no gain is realized. The additional income tax liability that [TO GENERATE] by the inclusion of the gain on the sale in the computation of taxable income is simply not incurred, as there was no sale and no realized gain.
(Adapted from Wikipedia: en.w ikipedia.org/w iki/Tax_evasion)
honest-to-goodness android, so lifelike that it seems like
a real person. It has moist lips, glossy hair and vivid
eyes that blink slowly. Seated on a stool with hands
5 folded primly on its lap at the 2005 World Exposition in
Japan's Aichi prefecture, it wore a bright pink blazer and
gray slacks. For a mesmerizing few seconds from several
meters away, Repliee was virtually indistinguishable from
an ordinary woman in her 30s. In fact, it was a copy of
10 one.
Japan is proud of the most advanced humanoids in
the world, which are expected to eventually be used as
the workforce diminishes among the decreasing and aging
population. But why build a robot with pigmented silicone
15 skin, smooth gestures and even makeup? To Repliee's
creator, Hiroshi Ishiguro, Director of Osaka University's
Intelligent Robotics Laboratory, the answer is simple:
"Android science."
Besides the justification for making robots
20 anthropomorphic and bipedal so they can work in human
environments with architectural features such as stairs,
Ishiguro believes that people respond better to very
humanlike automatons. Androids can thus elicit the most
natural communication. "Appearance is very important
25 to have better interpersonal relationships with a robot,"
says the 42-year-old Ishiguro. "Robots are information
media, especially humanoid robots. Their main role in
our future is to interact naturally with people."
Mild colorblindness forced Ishiguro to abandon his
30 aspirations of a career as an oil painter. Drawn to
computer and robot vision instead, he built a guide robot
for the blind as an undergraduate at the University of
Yamanashi. A fan of the android character Data from the
Star Trek franchise, he sees robots as the ideal vehicle
35 to understand more about ourselves.
To imitate human looks and behavior successfully,
Ishiguro combines robotics with cognitive science. In turn,
cognitive science research can use the robot to study
human perception, communication and other faculties.
40 This novel cross-fertilization is what Ishiguro describes
as android science. In a 2005 paper, he and his
collaborators explained it thus: "To make the android
humanlike, we must investigate human activity from the
standpoint of cognitive science, behavioral science and
45 neuroscience, and to evaluate human activity, we need
to implement processes that support it in the android."
One key strategy in Ishiguro's approach is to model
his artificial creations on real people. He began research
four years ago with his then four-year-old daughter,
50 casting a rudimentary android from her body, but its
mechanisms resulted in strange, unnatural motion.
Humanlike robots run the risk of compromising
people's comfort zones. Because the android's
appearance is very similar to that of a human, any subtle
55 differences in motion and responses will make it seem
strange. Repliee, though, is so lifelike that it has
overcome the creepiness factor, partly because of the
natural way it moves.
Ishiguro wants his next android, a male, to be as
60 authentic as possible. The model? Himself. The scientist
thinks having a robot clone could ease his busy schedule:
he could dispatch it to classes and meetings and then
teleconference through it. "My question has always been,
Why are we living, and what is human?" he says. An
65 Ishiguro made of circuitry and silicone might soon be
answering his own questions.
adapted from www.scientificamerican.com - May 2006
on many factors - how the energy is being used, where
it is being used, what energy sources are available,
which sources are most convenient and reliable, which
5 are easiest to use, what each costs, and the effects on
public safety, health, and the environment. Making smart
energy choices means understanding resources and their
relative costs and benefits.
Some energy sources have advantages for specific
10 uses or locations. For example, fuels from petroleum
are well suited for transportation because they pack a
lot of energy in a small space and are easily transported
and stored. Small hydroelectric installations are a good
solution for supplying power or mechanical energy close
15 to where it is used. Coal is widely used for power
generation in many fast-developing countries - including
China, India, and many others - because domestic
supplies are readily available.
Efficiency is an important factor in energy costs.
20 How efficiently can the energy be produced, delivered,
and used? How much energy value is lost in that process,
and how much ends up being transformed into useful
work? Industries that produce or use energy continually
look for ways to improve efficiency, since this is a key to
25 making their products more competitive.
The ideal energy source - cheap, plentiful, and
pollution-free - may prove unattainable in our lifetime,
but that is the ultimate goal. The energy industry is
continuing to improve its technologies and practices, to
30 produce and use energy more efficiently and cleanly.
Energy resources are often categorized as
renewable or nonrenewable.
Renewable energy resources are those that can be
replenished quickly - examples are solar power,
35 biomass, geothermal, hydroelectric, wind power, and
fast-reaction nuclear power. They supply about seven
percent of energy needs in the United States; the other
93 percent comes from nonrenewables. The two largest
categories of renewable energy now in use in the U.S.
40 are biomass - primarily wood wastes that are used by
the forest products industry to generate electricity and
heat - and hydroelectricity.
Nonrenewable energy resources include coal, oil,
natural gas, and uranium-235, which is used to fuel
45 slow-reaction nuclear power. Projections of how long a
nonrenewable energy resource will last depend on many
changeable factors. These include the growth rate of
consumption, and estimates of how much of the remaining
resources can be economically recovered. New exploration
50 and production technologies often increase the ability of
producers to locate and recover resources. World
reserves of fossil energy are projected to last for many
more decades - and, in the case of coal, for centuries.
In: http://www.classroom-energy.org/teachers/energy_tour/pg5.html
Your answers to questions 33 to 37 must be based
on the text below, which is entitled "Young, liberal
and in command":
Young, liberal and in command
Source: www.economist.co.uk
April 16, 2004 (Adapted)
On Thursday April 15th, the challengers won a
crucial battle in their bid to overturn South Korea's
conservative, elitist and business-driven political
system. . (1) the country's voters . (1.1) able to
choose their leaders freely since the late 1980s, many
of them, especially younger ones, still consider their
brand of democracy to be corrupt, outdated and unfair.
Many of the discontented admit . (2) enjoyed the
comforts that decades of market-friendly policies and
high growth have delivered. But they resent the . (3)
and . (3.1) dominance of giant family-controlled
business conglomerates, known as chaebol. Their
feelings towards the United States, a crucial ally, range
from ambivalent to hostile, and they would rather . (4)
with North Korean threats by placating its prickly regime
than by standing up to it. And now, they have convinced
mainstream voters to let them . (5) the country for the
next four years.
Analyze the following grammatical alternatives in order
to choose the appropriate one to fill in each of the
numbered gaps:
The hard cell
Thanks to politics, stem cell research in the United States is suffering. But not so in Sweden, which is poised to capture what could be the biggest new market to hit biotech in a decade.
By Stephan Herrera
February 13, 2003
New York, January 1, 2006:
Sweden announces that one of its biotechnology companies is the first in the world to enter clinical trials with a new drug that could cure Alzheimer's disease. Four years ago this type of research was all but stopped in the United States by political and ethical questions − which is ...61... Sweden now seems in the best position to capture a $25 billion market.
Any day now, the U.S. Congress is expected to pass a sweeping new law that could dramatically inhibit researchers from working with stem cells taken from human embryos. Such cells, which can be used to grow a whole host of new cells and organs, could fundamentally change the way we treat heretofore intractable maladies like Alzheimer's disease, Parkinson's disease, cancer, stroke, liver failure, and heart disease. The only problem is that these cells by definition are derived from human embryos, many of which are cloned or come from unused fetuses collected at fertility clinics. The argument, from a certain segment of the American political spectrum, is that ...62... methods are morally wrong. They are ...63... a form of abortion or an activity that could eventually lead to human cloning.
Those working in stem cell research say the short-term effect of the legislation will be to further chill all forms of scientific inquiry and commercialization efforts in the field. Entrepreneurs and investors are already eschewing such research − in large part because of the additional uncertainty and risk that politics introduce.
Of the nearly 50 private stem cell companies in the United States, only a handful are still viable. Meanwhile, across the Atlantic, Sweden has avoided many of the political and ethical quagmires surrounding this type of research. It currently has 40 private stem cell companies, a number that's growing. Sweden's leading research universities have 32 percent of the world's stem cell inventory, close on the heels of the United States' 35 percent.
Sweden, say analysts, is now in the best position to
capture a worldwide market for drugs based on stem cell
therapies that could grow to $25 billion in the next three to five
years − nearly equal to the whole biotech industry at present.
This estimate doesn't even address the market for stem cells
capable of repairing damaged vital organs like the brain, heart,
and kidneys. If the United States offers an object lesson of what
can happen when scientific inquiry and investment capital fall victim to politics, Sweden and its leading stem cell startup,
NeuroNova, offer the opposite example. How odd that the
United States, which for generations has been the envy of the
world for its progressive views of science and commercialization,
should now have a biomedical climate chillier than a Swedish
winter.
One company feeling a lot of pain is StemCells, which at first glance seems to have it all: founding scientists include Stanford's Dr. Weissman and Fred Gage of the Salk Institute in La Jolla, California. An equally well-regarded expert in the treatment of Alzheimer's, Dr. Gage spent five years in Sweden as a researcher and now sits on a national committee on stem cell research there. The firm's chairman is Roger Perlmutter, Amgen's head of research.
Yet over the past two years, none of management's efforts to help investors and even critics reconsider the stem cell field have worked. At press time, the stock was thinly traded and sitting in the neighborhood of 50 cents. With less than $15 million in cash, the company likely won't exist at this time next year. (CEO Martin McGlynn, who joined the firm in January 2001, would not talk to Red Herring, despite repeated efforts.)
Some observers on Wall Street are asking, If StemCells can't make it, who can? Geron, the only other publicly held stem cell firm to speak of, is in a fix, too. The company's stock price is also moribund, at $3.85 per share. Thanks to some capital infusions a few years ago, when money came easy, Geron still has $40 million on hand, but by the end of next year, that too will likely be gone. Once a media darling, Geron focuses on diagnostic tests and drugs derived from stem cells, a strategy that's not going well. For the nine months ended last September, revenue fell 68 percent to $955,000 and net loss widened 18 percent to $26.7 million. The company's financials were also hit hard after it terminated an agreement with Pharmacia and acquired research technology from Lynx Therapeutics, which Geron bought in a desperate attempt to be seen as something more than just a stem cell company.
The situation is quite different, however, for Sweden's NeuroNova, which has 30 academic partners and a staff of 20. NeuroNova is working on ways to inject stem cells into the human brain to trigger a process called neurogenesis (the growth of new neural cells), which could combat diseases like Parkinson's, Alzheimer's, and even schizophrenia.
If NeuroNova is the first to develop a drug capable of
treating one of several central nervous system disorders − by far
the most lucrative after heart disease products − it will have
done so not because it raised more money or got more media
buzz than the rest. It will have succeeded because the science
is solid, and academe, government, and the investment
community are supportive. Meanwhile, the United States will
look on with envy and wonder how it, a country known for its
entrepreneurial innovation, ever got so short-sighted.
(Adapted from
http://www.redherring.com/investor/2003/02/biotech021303.html)
The hard cell
Thanks to politics, stem cell research in the United States is suffering. But not so in Sweden, which is poised to capture what could be the biggest new market to hit biotech in a decade.
By Stephan Herrera
February 13, 2003
New York, January 1, 2006:
Sweden announces that one of its biotechnology companies is the first in the world to enter clinical trials with a new drug that could cure Alzheimer's disease. Four years ago this type of research was all but stopped in the United States by political and ethical questions − which is ...61... Sweden now seems in the best position to capture a $25 billion market.
Any day now, the U.S. Congress is expected to pass a sweeping new law that could dramatically inhibit researchers from working with stem cells taken from human embryos. Such cells, which can be used to grow a whole host of new cells and organs, could fundamentally change the way we treat heretofore intractable maladies like Alzheimer's disease, Parkinson's disease, cancer, stroke, liver failure, and heart disease. The only problem is that these cells by definition are derived from human embryos, many of which are cloned or come from unused fetuses collected at fertility clinics. The argument, from a certain segment of the American political spectrum, is that ...62... methods are morally wrong. They are ...63... a form of abortion or an activity that could eventually lead to human cloning.
Those working in stem cell research say the short-term effect of the legislation will be to further chill all forms of scientific inquiry and commercialization efforts in the field. Entrepreneurs and investors are already eschewing such research − in large part because of the additional uncertainty and risk that politics introduce.
Of the nearly 50 private stem cell companies in the United States, only a handful are still viable. Meanwhile, across the Atlantic, Sweden has avoided many of the political and ethical quagmires surrounding this type of research. It currently has 40 private stem cell companies, a number that's growing. Sweden's leading research universities have 32 percent of the world's stem cell inventory, close on the heels of the United States' 35 percent.
Sweden, say analysts, is now in the best position to
capture a worldwide market for drugs based on stem cell
therapies that could grow to $25 billion in the next three to five
years − nearly equal to the whole biotech industry at present.
This estimate doesn't even address the market for stem cells
capable of repairing damaged vital organs like the brain, heart,
and kidneys. If the United States offers an object lesson of what
can happen when scientific inquiry and investment capital fall victim to politics, Sweden and its leading stem cell startup,
NeuroNova, offer the opposite example. How odd that the
United States, which for generations has been the envy of the
world for its progressive views of science and commercialization,
should now have a biomedical climate chillier than a Swedish
winter.
One company feeling a lot of pain is StemCells, which at first glance seems to have it all: founding scientists include Stanford's Dr. Weissman and Fred Gage of the Salk Institute in La Jolla, California. An equally well-regarded expert in the treatment of Alzheimer's, Dr. Gage spent five years in Sweden as a researcher and now sits on a national committee on stem cell research there. The firm's chairman is Roger Perlmutter, Amgen's head of research.
Yet over the past two years, none of management's efforts to help investors and even critics reconsider the stem cell field have worked. At press time, the stock was thinly traded and sitting in the neighborhood of 50 cents. With less than $15 million in cash, the company likely won't exist at this time next year. (CEO Martin McGlynn, who joined the firm in January 2001, would not talk to Red Herring, despite repeated efforts.)
Some observers on Wall Street are asking, If StemCells can't make it, who can? Geron, the only other publicly held stem cell firm to speak of, is in a fix, too. The company's stock price is also moribund, at $3.85 per share. Thanks to some capital infusions a few years ago, when money came easy, Geron still has $40 million on hand, but by the end of next year, that too will likely be gone. Once a media darling, Geron focuses on diagnostic tests and drugs derived from stem cells, a strategy that's not going well. For the nine months ended last September, revenue fell 68 percent to $955,000 and net loss widened 18 percent to $26.7 million. The company's financials were also hit hard after it terminated an agreement with Pharmacia and acquired research technology from Lynx Therapeutics, which Geron bought in a desperate attempt to be seen as something more than just a stem cell company.
The situation is quite different, however, for Sweden's NeuroNova, which has 30 academic partners and a staff of 20. NeuroNova is working on ways to inject stem cells into the human brain to trigger a process called neurogenesis (the growth of new neural cells), which could combat diseases like Parkinson's, Alzheimer's, and even schizophrenia.
If NeuroNova is the first to develop a drug capable of
treating one of several central nervous system disorders − by far
the most lucrative after heart disease products − it will have
done so not because it raised more money or got more media
buzz than the rest. It will have succeeded because the science
is solid, and academe, government, and the investment
community are supportive. Meanwhile, the United States will
look on with envy and wonder how it, a country known for its
entrepreneurial innovation, ever got so short-sighted.
(Adapted from
http://www.redherring.com/investor/2003/02/biotech021303.html)

