Complications of Replacement Therapy

Complications of replacement therapy include:

- Developing antibodies (proteins) that attack the clotting factor
- Developing viral infections from human clotting factors
- Damage to joints, muscles, or other parts of the body resulting from delays in treatment

Antibodies to the clotting factor.

Antibodies can destroy the clotting factor before it has a chance to work. This is a very serious problem. It prevents the main treatment for hemophilia (replacement therapy) from working. These antibodies, also called inhibitors, develop in about 20-30 percent of people who have severe hemophilia A. Inhibitors develop in 2-5 percent of people who have hemophilia B
When antibodies develop, doctors may use larger doses of clotting factor or try different clotting factor sources. Sometimes the antibodies go away. Researchers are studying new ways to deal with antibodies to clotting factors.

Viruses from human clotting factors.

Clotting factors made from human blood can carry the viruses that cause HIV/AIDS and hepatitis. ....I.... , the risk of getting an infectious disease from human clotting factors is very small due to:

- Careful screening of blood donors
- Testing of donated blood products
- Treating donated blood products with a detergent and heat to destroy viruses - Vaccinating people who have hemophilia for hepatitis A and B

Damage to joints, muscles, and other parts of the body.

Delays in treatment can cause damage such as:

- Bleeding into a joint. If this happens many times, it can lead to changes in the shape of the joint and impair the joint's function.
- Swelling of the membrane around a joint. - Pain, swelling, and redness of a joint.
- Pressure on a joint from swelling, which can destroy the joint.

(Adapted from http://www.nhlbi.nih.gov/health/health-topics/ topics/hemophilia/treatment.html)

The US Department of Energy is giving $120m (£75m) to set up a new research centre charged with developing new methods of rare earth production.

Rare earths are 17 chemically similar elements crucial to making many hi-tech products, such as phones and PCs. The Critical Materials Institute will be located in Ames, Iowa.

The US wants to reduce its dependency on China, which produces more than 95% of the world’s rare earth elements, and address local shortages. According to the US Geological Survey, there may be deposits of rare earths in 14 US states. Besides being used for hi-tech gadgets, the elements are also crucial for manufacturing low-carbon resources such as wind turbines, solar panels and electric cars, said David Danielson, the US assistant secretary for renewable energy.

Rare earth elements are also used for military applications, such as advanced optics technologies, radar and radiation detection equipment, and advanced communications systems, according to a 2011 research report by the US Government Accountability Office. From the 1960s until the 1980s, the Mountain Pass mine in California made the US the world leader in rare earth production, but it was later closed, largely due to competition with the elements imported from China.

At the moment, the regulations surrounding rare earths mining in the US are very strict, an expert on the materials from Chalmers University of Technology in Sweden told the BBC. “The Mountain Pass mine was [also] closed down for environmental reasons,” said Prof Ekberg.

Brazil’s Average Unemployment Rate Falls to Record Low in 2012

By Dow Jones Business News

January 31, 2013

            Brazil’s unemployment rate for 2012 fell to 5.5%, down from the previous record low of 6.0% recorded last year, the Brazilian Institute of Geography and Statistics, or IBGE, said Thursday. In December, unemployment fell to 4.6% compared with 4.9% in November, besting the previous record monthly low of 4.7% registered in December 2011, the IBGE said
            The 2012 average unemployment rate was in line with the 5.5% median estimate of economists polled by the local Estado news agency. Analysts had also pegged December’s unemployment rate at 4.4%.
            Brazil’s unemployment rate remains at historically low levels despite sluggish economic activity. Salaries have also been on the upswing in an ominous sign for inflation - a key area of concern for the Brazilian Central Bank after a series of interest rate cuts brought local interest rates to record lows last year. Inflation ended 2012 at 5.84%.
            The average monthly Brazilian salary retreated slightly to 1,805.00 Brazilian reais ($908.45) in December, down from the record high BRL1,809.60 registered in November, the IBGE said. Wages trended higher in 2012 as employee groups called on Brazilian companies and the government to increase wages and benefits to counter higher local prices. Companies were also forced to pay more to hire and retain workers because of the country’s low unemployment.
The IBGE measures unemployment in six of Brazil’s largest metropolitan areas, including São Paulo, Rio de Janeiro, Salvador, Belo Horizonte, Recife and Porto Alegre. Brazil’s unemployment rate, however, is not fully comparable to jobless rates in developed countries as a large portion of the population is either underemployed or works informally without paying taxes. In addition, workers not actively seeking a job in the month before the survey don’t count as unemployed under the IBGE’s methodology. The survey also doesn’t take into account farm workers.

                                    (www.nasdaq.com. Adaptado)